Work

Long-lived states involving a manifold of fluorine-19 spins in fluorinated aliphatic chains

Year: 2025

Type: article

Abstract: . Long-lived states (LLS) have lifetimes TLLS that exceed longitudinal spin-lattice relaxation times T1. In this study, lifetimes TLLS (19F) have been measured in three different achiral per- and polyfluoroalkyl substances (PFAS) containing 2 or 3 consecutive CF2 groups. In a static magnetic field B0 = 11.6 T, the lifetimes TLLS(19F) exceed the longitudinal relaxation times T1(19F) by about a factor of 3. The lifetimes TLLS(19F) can be strongly affected by binding to macromolecules, a feature that can be exploited for the screening of fluorinated drugs. Both TLLS(19F) and T1(19F) should be longer at low fields where relaxation due to the chemical shift anisotropy (CSA) of 19F is less effective, as will be shown elsewhere.

Source: Magnetic Resonance

DOI: 10.5194/mr-6-273-2025

Authors: Coline Wiame, Sebastiaan Van Dyck, Kirill Sheberstov, Aiky Razanahoera, Geoffrey Bodenhausen

Institutions: Centre National de la Recherche Scientifique, Université Paris Sciences et Lettres, École Normale Supérieure - PSL, Sorbonne Université, Chimie Physique et Chimie du Vivant

Language: English

Topic: Advanced NMR Techniques and Applications

Subfield: Spectroscopy

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $992

Funders: Agence Nationale de la Recherche, HORIZON EUROPE Framework Programme, HORIZON EUROPE European Research Council