Year: 2025
Type: article
Abstract: Duck hepatitis A virus type 3 (DHAV-3), an avian-specific pathogen primarily impacting ducklings, poses a significant threat to the duck farming industry by causing high mortality rates. A DHAV-3 strain SH52 was isolated from the diseased ducks and phylogenetic analysis of the whole genome revealed that the DHAV-3 SH52 belongs to the prevalent strains in China. The DHAV-3 SH52 strain replicates at high levels in various organs of 8-day-old specific pathogen-free (SPF) shelducks, causing pathological damage and leading to high lethality in 8-day-olds following intramuscular infection. The findings of this study provide an ideal animal challenge model for evaluating the efficacy of DHAV-3 vaccines in the future.
Source: Microorganisms
Authors: Minfan Huang, Dun Shuo, Yifei Xiong, Mei Tang, Yufei Wang, Xue Pan, Chunxiu Yuan, Qinfang Liu, Zhifei Zhang, Qiaoyang Teng, Bangfeng Xu, Xiaona Shi, Minghao Yan, Peirong Jiao, Zejun Li, Dawei Yan
Language: English
Subfield: Animal Science and Zoology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,258
OpenAlex ID: W7106580889