Association of Concomitant COVID-19 Infection With Outcomes in Patients With Acute Cardiovascular Diseases ― Nationwide Study Using the JROAD Database in Japan ―
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background: Although the COVID-19 pandemic altered hospitalization trends for acute cardiovascular diseases (CVD) in Japan, the effects of a concomitant COVID-19 diagnosis on mortality in this high-risk population remains unclear. We investigated the association between COVID-19 infection and 30-day mortality among patients hospitalized for acute CVD using a nationwide database. Methods and Results: This retrospective cohort study used data from the Japanese Registry of All Cardiac and Vascular Diseases-Diagnosis Procedure Combination (JROAD-DPC) database from January 2020 to March 2022. We included patients hospitalized for acute myocardial infarction, acute heart failure, aortic rupture, or venous thromboembolism. We compared patients with and without COVID-19, with 30-day mortality as the primary outcome. We used 1 : 1 propensity score matching to balance baseline patient and hospital characteristics. Of 395,671 eligible patients in the JROAD-DPC database, 41,794 (10.6%) had a concomitant COVID-19 diagnosis. In the matched cohort of 41,794 pairs, the risk of 30-day mortality was significantly higher patients for patients with than without COVID-19 (6.6% vs. 5.8%; odds ratio 1.14; 95% confidence interval 1.08-1.21; P<0.001). This increased risk was consistent across all major diagnostic subgroups (P for interaction >0.3). Conclusions: In this large nationwide study of patients hospitalized for acute CVD in Japan, concomitant COVID-19 infection was associated with a significant increase in 30-day mortality. These findings suggest that COVID-19 infection is associated with increased mortality in this vulnerable patient population.
Source: Circulation Reports
Authors: Tadafumi Sugimoto, Atsushi Mizuno, Daisuke Yoneoka, Shingo Matsumoto, Chisa Matsumoto, Yuya Matsue, Mari Ishida, Koshiro Kanaoka, Yoshitaka Iwanaga, Yoshihiro Miyamoto, Koichi Node
Institutions: Mie University, Nagoya City University Mirai Kousei Hospital, St. Luke's International Hospital, University of Pennsylvania Health System, Leonard Davis Institute of Health Economics, University of Pennsylvania, National Institute of Infectious Diseases, Toho University, Tokyo Medical University, Juntendo University, Hiroshima University, National Cerebral and Cardiovascular Center, Sakurabashi Watanabe Hospital, Saga University
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7106707259