Work

Synthesis of Modified Fusicoccane Diterpenoids via Diverging MHAT Reactivity

Year: 2025

Type: article

Abstract: Cotylenin and fusicoccin diterpene glycosides modulate the stability of 14-3-3 protein-client interactions. Here, we report the divergent syntheses of representative aglycons, brassicicene (BR-I), and talarmalnoid B (Tal-B) by modification of Studer's Mukaiyama hydration variant.

Source: Synthesis

DOI: 10.1055/a-2744-6756

Authors: Dylan W. Snelson, Sebastian A. Fernandez, Ryan A. Shenvi

Language: English

Topic: Biological Activity of Diterpenoids and Biflavonoids

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Institutes of Health, National Science Foundation Graduate Research Fellowship Program

Awards: G3947575498, Unusual Pharmacophores and New Tools for Cross-Coupling

OpenAlex ID: W7107865067

FWCI:

Cites: 25

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