Iron catalysed decarboxylative oxidation photocatalysis of alpha-carbon to access aldehyde/ketone from aryl aliphatic carboxylic acid
Year: 2025
Type: article
Abstract: Carbonyl-containing compounds, such as aldehydes and ketones, are fundamental to synthetic organic chemistry, with wide-ranging applications in the pharmaceutical industry. In this study, we introduce an efficient and streamlined metallophotoredox approach for decarboxylative oxygenation via visible-light-induced ligand-to-metal charge transfer (LMCT). Our method simplifies the transformation of aryl aliphatic carboxylic acids into their corresponding aryl aldehydes and ketones, utilizing iron(III) triflate as a photo catalyst in the presence of TMEDA as a ligand. This strategy not only enhances environmental sustainability but also expands the potential for late-stage functionalization of complex molecules and bioactive compounds.
Source: OICC Press Journals
Authors: Katiyar, Raunak, Kumar, Sumit, Khatik, Gopal L.
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W7107943167