Alzheimer’s disease classification from EEG using a multiscale temporal deep network
Year: 2025
Type: article
Abstract: Early and accurate diagnosis of Alzheimer’s Disease (AD) is crucial for patient care and intervention but remains challenging due to the complexity and variability of clinical data. Electroencephalography (EEG) has emerged as a promising, non-invasive, and cost-effective tool to detect brain activity patterns associated with AD. In this work, we introduce a lightweight Multiscale Temporal Deep Network (MTDNet) that integrates multiple temporal convolutions with recurrent modeling to capture both short- and long-term EEG patterns. Two patient-level classification strategies are also proposed that combine segment-level EEG predictions based on consensus and score aggregation to better align with clinical practice and utility. We evaluate our method on four benchmark EEG datasets (ADSZ, APAVA, ADFTD, BrainLat) where it consistently outperforms state-of-the-art solutions by about 2% at the segment level and by about 6% at the patient level on the most challenging datasets. Unlike recent computationally heavy transformer-based solutions, MTDNet achieves superior accuracy with only 20.5K parameters and 1.8M FLOPs, enabling its deployment in resource-constrained environments. Ablation studies confirm the critical contribution of the multiscale design and show that simple augmentation techniques increase generalization and robustness. Code is available at https://github.com/unimib-islab/MTDNet .
Authors: Simone Zini, Thomas Barbera, Simone Bianco, Paolo Napoletano
Institution: University of Milano-Bicocca
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $2,590
OpenAlex ID: W7108325156