Intestinal macrophages modulate synucleinopathy along the gut-brain axis
Year: 2025
Type: article
Abstract: We generated a digital spatial profiling (DSP) dataset from duodenal myenteric plexus of 3-month-old 3KL and WT mice, analyzing 2–3 ROIs per slide across 2 animals per genotype. The dataset comprises expression values for 25 proteins, including PD-associated targets, lysosomal and autophagy markers, internal housekeeping and background controls. Normalized digital counts were obtained per ROI, enabling comparative analysis of protein signatures between genotypes at an early stage of pathology
Authors: De Schepper, Sebastiaan, Konstantellos, Viktoras, Conway, James, Sokolova, Dimitra, Zaccagnini, Ludovica, Cowley, Matthew, Sierksma, Annerieke, Yudina, Maria, Edmonds, Marisa, Gavriouchkina, Daria, Geary, Bethany, Wallis, Amber, Celikag, Meral, Baykam, Zeynep, Vara-Pérez, Mónica, Crowley, Gerard, Hager, Fabian Tobias, Bijnen, Mitchell, Posner, David, Luk, Kelvin, Cerovic, Vuk, Clatworthy, Menna, Videlock, Elisabeth Jane, Jaunmuktane, Zane, Movahedi, Kiavash, Greter, Melanie, Chain, Benny, Alessi, Dario R., Hong, Soyon, Bartels, Tim
Institutions: VIB-UAntwerp Center for Molecular Neurology, UK Dementia Research Institute, University College London, VIB-KU Leuven Center for Brain & Disease Research, Vrije Universiteit Brussel, RWTH Aachen University, University of Zurich, University of Cambridge, University of Pennsylvania, University of California, Los Angeles, University of Dundee
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7108444593