Work

Theoretical study on the multi-mechanism synergistic bactericidal effect of asymmetric Janus AuNPs–PS microspheres

Year: 2025

Type: article

Abstract: under multi-mechanism synergy. Simulation results indicate that the synergistic effect of multiple mechanisms yields a bactericidal efficacy approximately 30% higher than that of a single strategy. Among these, UV itself has a bactericidal effect. Relevant literature indicates that AuNPs can generate high temperatures under the photothermal effect, thereby disrupting bacterial membrane structures to a certain extent. Furthermore, the photocatalytic effect on the AuNP surface can catalyze the production of large amounts of reactive oxygen species (ROS) under appropriate conditions, facilitating the inactivation of certain bacteria. The PS matrix serves as an ideal carrier for AuNPs, with its excellent functionalization and dielectric properties providing the foundation for DEP manipulation. Furthermore, the spatial targeting and enrichment effect of DEP significantly enhances the local microsphere concentration and contact efficiency with bacteria. This multi-synergistic approach combining "physical enrichment-photothermal-photocatalysis" offers a potential strategy for overcoming bacterial resistance barriers. Under simulated conditions, it demonstrates promising removal potential against persistent biofilms, providing a theoretical mechanism for combating drug-resistant bacterial infections without readily inducing resistance. However, this inference requires validation through biological experiments. The study aims to provide theoretical foundations and simulation guidance for developing highly efficient sterilization technologies.

Source: Nanoscale Advances

DOI: 10.1039/d5na00955c

Authors: Lingcong He, Hongyang Xu, Yonghui Yang, Xue-Bo Chen

Institution: University of Science and Technology Liaoning

Language: English

Topic: Nanoparticles: synthesis and applications

Subfield: Materials Chemistry

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,962