Work

Gastrointestinal stromal tumor liver metastasis rupture following yttrium-90 radioembolization: A previously unreported complication

Year: 2025

Type: article

Abstract: Gastrointestinal stromal tumors (GISTs) commonly arise in the gastrointestinal tract and frequently metastasize to the liver. While medical therapy is the first-line treatment, loco-regional approaches such as selective internal radiation therapy (SIRT) may be pursued in refractory cases. Here, we present the case of a 60-year-old woman with a GIST and hepatic metastases who underwent SIRT, which was complicated by tumor rupture. This previously unreported complication necessitated further evaluation to rule out intra-abdominal dissemination of Y90 particles but fortunately did not require additional intervention. This case highlights a rare and potentially life-threatening complication of SIRT for GIST metastases, underscoring the need for vigilance and prompt recognition to guide appropriate management.

Source: Radiology Case Reports

DOI: 10.1016/j.radcr.2025.11.036

Authors: William D. Denton, Christopher A. Jackel, Gaby E. Gabriel

Institution: University of Kentucky

Language: English

Topic: Gastrointestinal Tumor Research and Treatment

Subfield: Gastroenterology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $600