The importance of laboratory analyses in unmasking parathyroid adenoma in a patient with breast cancer: a case report of persistent hypercalcaemia with low vitamin D status
Year: 2025
Type: article
Study design: Case Report
Abstract: Background: Parathyroid adenoma is a frequent cause of hyperparathyroidism. Its association with D hypovitaminosis can complicate this pathological state, especially in case of delayed surgical intervention. Case presentation: This case report presents a 77-year-old female patient with a complex medical history including dyslipidemia, hypertension, who developed primary hyperparathyroidism due to a parathyroid adenoma. The persistent hypercalcemia, elevated parathyroid hormone (PTH), and parathyroid scintigraphy led to the diagnosis, but the low 25-hydroxyvitamin D level complicated the picture. Due to personal decisions and the COVID-19 pandemic, surgery was delayed for six years, resulting in complications such as vitamin D deficiency-induced immunosuppression and osteoporosis. Post-surgical outcomes were favorable, with normalization of biochemical markers and stabilization of comorbid conditions. Conclusion: This case highlights that timely multidisciplinary management is essential in primary hyperthyroidism, as surgical delay worsens complications, yet parathyroidectomy can still reverse outcomes even after years of progression.
Authors: Anna Zsófia Puskás, Enikő Nemes-Nagy, Róbert Nemes-Nagy, Melinda Kolcsár
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7109544156
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