Year: 2025
Type: article
Abstract: Helical peptides are primarily stabilized by intramolecular hydrogen bonds. Particular conformational arrangements, capping motifs, help precisely terminate helices by compensating for disruption of helical H-bonding patterns. This contribution explores if: (i) N-and C-caps are essentially the same; and, (ii) how differences impact their thermodynamic helix stabilities and folding kinetics.
Source: Chemical Communications
DOI: 10.1039/d5cc04856g
Authors: Tianxiong Mi, Lorenz Mattes, Thitima Pewklang, Karin Hauser, Kevin Burgess
Institutions: Texas A&M University, University of Konstanz
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W7110412900