Work

Heroin self-administration induces sex-specific SUMOylation at early abstinence

Year: 2025

Type: article

Abstract: Introduction: Opioid use disorder, particularly heroin use disorder (HUD), is a major medical challenge, marked by severe withdrawal symptoms and a high risk of relapse. Heroin abuse leads to severe withdrawal and high relapse rates, with neuroadaptations contributing to relapse. Sex-specific differences in heroin-induced neuroadaptations are poorly understood, limiting effective therapies. Posttranslational modifications (PTMs), such as SUMOylation, play a key role in regulating protein function and neuroplasticity. SUMOylation attaches SUMO proteins to lysine residues, altering protein activity and influencing addiction mechanisms. Understanding sex-specific PTMs like SUMOylation could reveal new therapeutic targets for heroin addiction.

Source: SHAREOK (University of Oklahoma; Oklahoma State University; Central Oklahoma University)

Authors: Chakraborty, Songjukta, Preveza, Natalie J., Jeffers, Ann, Hochstetler, Mason, Dodge, Anastasia, Jarome, Timothy J., Mitra, Swarup

Language: English

Topic: Neurotransmitter Receptor Influence on Behavior

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7110467581

FWCI:

Cites:

Cited by:

Related to: