Work

Quantitative proteomic and phenotypic analysis of Chlamydomonas wild-type and lf4 mutant

Year: 2025

Type: article

Abstract: Background: Normal health and development require cilia and flagella, which are essential organelles that are highly conserved across different species. The molecular mechanisms that regulate their assembly state, however, remain largely unknown. In Chlamydomonas, mutations in any of five long flagella (lf) genes result in cells that assemble flagella more than twice the length of wild-type cells. To learn more about the role of one of these genes, LF4 (which encodes a MAP kinase) we used a phenotypic analysis along with a global proteomic approach to identify differentially expressed proteins in the flagella and cell bodies of lf4 and wild-type cells.

Source: SHAREOK (University of Oklahoma; Oklahoma State University; Central Oklahoma University)

Authors: Herath, Dilani, Wilson, Nedra

Language: English

Topic: Genetic and Kidney Cyst Diseases

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W7110551471

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