Stimulus input
Year: 2025
Type: dataset
Abstract: Models of visual salience detection rely on center–surround interactions, yet it remains unclear how these computations are distributed across retinal, cortical, and subcortical circuits due to their overlapping contributions. Here, we reveal a de novo collicular mechanism for surround suppression by combining patterned optogenetics with whole-cell recordings from individual neurons in the mouse superficial superior colliculus (SCs). Center zones were defined by monosynaptic input from channelrhodopsin-expressing retinal ganglion cells in collicular midbrain slices. Surround network optoactivation suppressed center responses compared to center-only input. This suppression is excitatory in origin, arising from the withdrawal of center excitation via surround-driven inhibition of local recurrent excitatory circuits, as demonstrated by cell-type-specific trans-synaptic tracing and computational modeling. These findings identify a local circuit mechanism for saliency computation in the SCs, independent of cortical input.
Authors: Cui, Peng, Song, Kuisong, Mariatos, Dimitrios, Isla, Arturo G., Femenía, Teresa, Lazaridis, Iakovos, Meletis, Konstantinos, Kumar, Arvind, Kardamakis, Andreas A.
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7110792379
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