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Solvent-free reactions at work towards densely functionalized targets: synthesis of 3-amino(azido)-3-deoxy- d -galactose, a key structural motif of galectin ligands

Year: 2025

Type: article

Abstract: 3-Deoxy-3-amino(azido)- d -galactose, key precursors of high-affinity inhibitors of galectins with therapeutic application, were synthesized through a straightforward pathway largely relying on solvent-free reactions.

Source: Organic & Biomolecular Chemistry

DOI: 10.1039/d5ob01710f

Authors: Serena Traboni, Emiliano Bedini, Fabiana Esposito, Marcello Ziaco, Alfonso Iadonisi

Institutions: University of Naples Federico II, Istituto di Chimica Biomolecolare, National Research Council

Language: English

Topic: Carbohydrate Chemistry and Synthesis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Funders: Università degli Studi di Napoli Federico II, Ministero dell'Università e della Ricerca

Awards: G126855529, G4781383950

OpenAlex ID: W7110889552

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Cites: 33

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