Work

Asociación entre el ancestro genético y los genotipos rs3827760 de EDAR en poblaciones latinoamericanas

Year: 2026

Type: article

Abstract: Introduction. The EDAR (ectodysplasin A receptor) gene is associated with the development of ectodermal structures. The rs3827760 variant is highly frequent in East Asian and Native American populations, and this study analyzes its relationship with genetic ancestry proportions in a Latin American population sample. Objective. To analyze how genetic ancestry proportions influence the distribution of single nucleotide polymorphism (SNP) rs3827760 genotypes of the EDAR gene in Latin American populations. Materials and methods. Genetic ancestry proportions were estimated using a panel of 446 ancestry-informative SNPs, applying the STRUCTURE program and univariate and multivariate logistic regression models. Results. Native American ancestry proportions showed a significant positive association with the prevalence of rs3827760 GG genotypes, while European ancestry showed a negative association. Conclusion. Native American and European genetic ancestry proportions influence the distribution of SNP rs3827760 genotypes of the EDAR gene in Latin American populations.

Source: Biomédica

DOI: 10.7705/biomedica.7693

Authors: Jorge Briceño, Ángel Roco-Videla, Germán Maríquez-Soto, Sergio V. Flores

Institutions: University of Chile, Universidad Católica de la Santísima Concepción, Universidad Católica Silva Henríquez, Arturo Prat University

Language: English

Topic: Forensic and Genetic Research

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: Agenția Națională pentru Cercetare și Dezvoltare, Agencia Nacional de Investigación y Desarrollo, CHIST-ERA