Year: 2025
Type: article
Study design: Case Report
Abstract: Papillary carcinoma arising in a thyroglossal duct cyst is a rare entity, accounting for approximately 1% of all thyroglossal cyst cases. Clinically, it often mimics a benign cystic lesion, making preoperative diagnosis difficult. In most instances, the malignancy is discovered incidentally during histopathological evaluation following surgical excision. We report two cases of papillary carcinoma arising in thyroglossal duct cysts in female patients aged 38 and 37 years, respectively. In both cases, the carcinoma was identified only after routine surgical excision performed for clinically benign-appearing cysts. Histopathological examination revealed features characteristic of papillary thyroid carcinoma originating within the thyroglossal duct cyst. These cases highlight the importance of thorough preoperative evaluation, including high-resolution ultrasound, to assess for solid components, calcifications, or other suspicious features. Furthermore, extensive histological sampling of excised thyroglossal duct cysts-particularly those with solid areas is essential to exclude the presence of malignancy.
DOI: 10.21276/apalm.3655
Authors: Niketa Tyagi, Monika B Gathwal, Kulwant Singh, Chiranjeev Gathwal, Ruchi Agarwal, Sawaran Kaur
Institution: Government of Haryana
Language: English
Topic: Head and Neck Anomalies
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7111151805
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