Year: 2025
Type: article
Abstract: Quercetin exhibits anti-inflammatory and antioxidant properties. Incorporating quercetin into liposomes can overcome its limited water solubility and poor oral bioavailability, making it a promising candidate for treating inflammatory diseases. For pulmonary administration, supercritical CO2-assisted spray drying can be used to convert liposomal suspensions into dry powder formulations suitable for inhalation. However, the extraction power of scCO2 can pose challenges on retaining the incorporation efficiency (IE) of this flavonoid in the lipid bilayer. This study focuses on optimizing quercetin's IE after drying using different liposomal lipid compositions with varying surface charges. The IE of quercetin into positively charged liposomes was 57 %. Additionally, the resulting powders had a mass median aerodynamic diameter of 1.7 µm and a fine particle fraction (particle size < 5 µm) of 63 %, indicating their suitability for inhalation. Cytotoxicity assays also revealed that both reconstituted liposomes and dry powder formulations were non-toxic to areolar fibroblast cells.
Authors: Costa, Clarinda, Grenho, Liliana, Casimiro, Teresa, Gomes, Pedro Sousa, Fernandes, Maria Helena, Corvo, M. Luisa, Aguiar-Ricardo, Ana
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Integrated Manufacture of Liposomal Dry Powder Formulations, G1240268737, G1364742672, G138060719, G1509028180, G1762135236, G1977608718, G2012127377, G2051880127, G2346795057, Laboratório Associado para a Química Verde - Tecnologias e Processos Limpos, Laboratório Associado para a Química Verde - Tecnologias e Processos Limpos, G2650697307, G2756637201, G2783038177, G2814222956, G3127682330, G332082475, G349060782, G3702813737, G4046065984, G4378797157, G5059362577, G5141657006, G567200461, G5743607198, G5868090805, G6113984419, G6119126181, G6463117426, G6997658380, G7906424758, G8213652065, G824076568, Instituto de Investigação do Medicamento, Laboratório Associado para a Química Verde - Tecnologias e Processos Limpos, G8963217260
OpenAlex ID: W7112335490