Современные Представления О Процессе Репарации
Year: 2016
Type: article
Abstract: DNA is the information-active chemical component of the genetic stuff of living cells. With this respect, it seems to possess the highest level of stability in order to effectively preserve the genetic information. In reality, however, the primary structure of DNA is the highly dynamic structure. It is subjected to permanent alterations initiated by endogenous metabolic factors as well as exogenous environmental factors. The endogenous factors of damage of DNA comprise the reactions of hydrolysis, oxidation, alkylation of nitrogen bases, and other chemical modifications. Among the exogenous damages, there are ionizing and UV irradiation and various active chemicals. At the level of cells, insufficient reparation of DNA damages may result in destabilization of genome, apoptosis, aging, mutations and cancer. In recent years, the great progress has been achieved in understanding the detail mechanisms that provide efficiency and reliability of the above mentioned reparation systems. In this communications, the progress in the understanding of detailed mechanisms of such reparation processes as the excision repair of damages in DNA induced by physical factors, the progress that has been achieved in the last few years, will be discussed.
Author: Корольов, Володимир Геннадійович
Language: Russian
Topic: DNA Repair Mechanisms
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7112538366