Onderzoek Naar Transport En Metabolisme Van Microbiële Metabolieten Bij Chronische Nierziekte: Inzichten in De Darm-nier-as
Year: 2025
Type: dissertation
Abstract: Structural and functional characterization of colonic tissue obtained from patients with chronic kidney disease (CKD) and from rodent animal models with the aforementioned induced pathology. Samples will be studied with different laboratory techniques including permeability analysis using Ussing chambers, relative gene and protein expression with qPCR and Western Blotting, among the others. A structural and functional characterization of transport mechanisms involved in metabolism and systemic excretion of uremic toxins of gut microbial origin such as indole and p-cresol uptake will be the main focus of the project.
Source: Lirias (KU Leuven)
Author: Lauriola, Mara
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7113098323
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