A case report of myelodysplastic and myeloproliferative neoplasms (MDS/MPN) with neutrophilia; an evidence of changes in their dynamics
Year: 2024
Type: article
Study design: Case Report
Abstract: Myelodysplastic and myeloproliferative neoplasms (MDS/MPN) with neutrophilia, previously referred to as atypical chronic myeloid leukaemia (aCML), constitute a disease entity of BCR-ABL1 negative MDS/MPN according to the new 5th edition World Health Organization (WHO) classification. It is characterized by an overlap syndrome that combines features of both myelodysplastic and myeloproliferative disorders, with a high propensity for progressing to acute myeloid leukaemia (AML) and an overall unfavourable prognosis. We report the case of a 72-year-old female who was referred to our hospital for further investigation of anaemia, thrombocytopaenia, and leucocytosis and was diagnosed with MDS/MPN with neutrophilia. Bone marrow morphology exhibited hypercellular marrow with dysplastic features in all three lineages. Our case report and literature review offer valuable insights into the dynamics of the morphological features of MDS/MPN with neutrophilia.
Authors: Mohd Tohit, Eusni Rahayu, Nazar Shah, Norhanis, Khalid, Bahariah, Md Noor, Sabariah
Institution: Universiti Putra Malaysia
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7113356129
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