Work

Revealing the Roles of the SH3GLB1-Hydrogen Peroxide Axis in Glioblastoma Multiforme Cells

Year: 2025

Type: article

Abstract: Objectives: reverses temozolomide (TMZ) resistance. Methods: signaling in cell state transitions and animal experiments identified optimal treatment strategies. Results: , which inhibited the aquaporin-9/AKT signaling. Conclusion: -SH3GLB1 signaling in GBM and may inform future therapeutic strategies for overcoming TMZ resistance.

Source: Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics

DOI: 10.32604/or.2025.071258

Authors: Wei-Ting Hsueh, Kwang-Yu Chang, Chin-Chuan Tsai, Kuan-Tso Chen, Kuen-Jang Tsai, Zi-Xuan Hong, Chan-Chuan Liu, Jui-Mei Chu, Li-Ying Qiu, Yu-Yan Lan, Chia-Hung Chien

Institutions: National Cheng Kung University Hospital, National Cheng Kung University, National Health Research Institutes, E-Da Hospital, I-Shou University

Language: English

Topic: Glioma Diagnosis and Treatment

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W7114900181

FWCI: 0.541

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Cited by: 1

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