Work

18 F-FDG PET/CT and 99m Tc-HFAPI SPECT/CT in a case of systemic sclerosis-associated interstitial lung disease

Year: 2025

Type: article

Abstract: Interstitial lung disease (ILD) is a common manifestation of connective tissue disease (CTD) and a substantial contributor to increased morbidity and mortality. 18 F-fluorodeoxyglucose ( 18 F-FDG) PET/CT and 99m Tc-HYNIC-fibroblast activation protein inhibitor ( 99m Tc-HFAPI) SPECT/CT were performed on a 25-year-old female patient with systemic sclerosis-associated ILD. Baseline imaging demonstrated increased uptake of both tracers in the peripheral lung parenchyma. After corticosteroids and antifibrotic agent treatment, worsening respiratory symptoms and declining pulmonary function were observed. Follow-up imaging showed reduced FDG uptake but increased and expanded HFAPI uptake, with no significant changes on high-resolution CT (HRCT). The discrepancy between FDG and HFAPI uptake indicated the heterogeneous fibrotic and inflammatory processes occurring in individual patients.

Source: Journal of Nuclear Medicine and Molecular Imaging

DOI: 10.65457/jnmmi-2025-0003

Authors: Jingnan Wang, Yu Liu, Xueyang Zhang, Yangzhong Zhou, Qian Wang, Li Huo

Institutions: Chinese Academy of Medical Sciences & Peking Union Medical College, Peking Union Medical College Hospital

Language: English

Topic: Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Natural Science Foundation of China, Peking Union Medical College Hospital, National Key Research and Development Program of China