Work

Spleen-targeted mRNA delivery via long-chain PEGylated lipids at low molar ratio enhances antitumor immunity against melanoma

Year: 2025

Type: article

Abstract: T cell populations, and significantly inhibited tumor growth in a B16-ovalbumin (OVA) melanoma model. Collectively, our results establish a rational strategy via precise PEGylated lipid engineering to redirect LNP biodistribution from the liver to the spleen. These findings validate the spleen as a critical target for mRNA vaccines and provide a versatile platform for next-generation cancer immunotherapies.

Source: Molecular Therapy — Nucleic Acids

DOI: 10.1016/j.omtn.2025.102803

Authors: Shiyu Liu, Longlong Zhang, Wenbo Wu, May Yee Chen, Feng Qian

Institution: Tsinghua University

Language: English

Topic: RNA Interference and Gene Delivery

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,900