Engineered polypeptide cascade-release platform restores macrophage plasticity for accelerated diabetic wound healing
Year: 2025
Type: article
Abstract: @PDA initiates a clearance program targeting dysregulated immune cells and concurrently reprograms the energy metabolism of newly recruited immune cells, thereby reshaping the immune niche to alleviate inflammation and activate tissue-regenerative programs for accelerated healing. Moreover, sustained low-dose nitric oxide release caused by arginine accelerates angiogenesis, which is beneficial for tissue regeneration. These findings expand the perspective on the intricate coordination of the immune system in diabetic wound repair and reveal new strategies for novel immunomodulatory biomaterials.
Source: Bioactive Materials
Authors: Hao Xia, Qi Tang, Zhen Chen, Shujun Cao, Lihuang Wu, Lili Hao, Xiulan Hu, Lingyun Sun, Zhongwei Gu, Hongli Mao
Language: English
Topic: Wound Healing and Treatments
Subfield: Rehabilitation
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,200
Funders: National Natural Science Foundation of China, Ministry of Science and Technology of the People's Republic of China, China Postdoctoral Science Foundation, Natural Science Foundation of Jiangsu Province, Jiangsu Science and Technology Department, Priority Academic Program Development of Jiangsu Higher Education Institutions, Graduate Research and Innovation Projects of Jiangsu Province, National Key Research and Development Program of China
OpenAlex ID: W7114996474