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Native Amide-Directed C(sp³)–H Alkynylation Using an Electron-Deficient Iridium Catalyst with Pyridone Ligand Assistance

Year: 2025

Type: article

Abstract: The direct functionalization of C(sp³)–H bonds assisted by native carbonyl functional groups is a promising strategy for the streamlined synthesis of complex molecules. Here, we report native amide-directed C(sp³)–H alkynylation reactions using an electron-deficient iridium catalyst and an electron-deficient pyridone ligand. Under the optimized conditions, the C(sp³)–H alkynylation of terminal methyl groups and internal methylene groups of cyclobutane carboxamides afforded the desired products in moderate to good yields.

Source: Kyoto University Research Information Repository (Kyoto University)

Authors: Kimura, Shunsuke, Kobayashi, Tomoaki, Hirata, Yuki, Higashida, Kosuke, Yoshino, Tatsuhiko, Matsunaga, Shigeki

Institution: Kyoto University

Language: English

Topic: Catalytic C–H Functionalization Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

OpenAlex ID: W7115040236

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