Year: 2025
Type: article
Study design: Observational Study
Abstract: This study assesses the influence of psycho-emotional stress on the immune mechanisms of the development of psoriasis in order to determine the relationship between stress load, the activation of neuroendocrine pathways and Th17-mediated inflammation. The analysis was carried out by comparing patients with psoriasis who had high and low levels of psycho-emotional stress. On the basis of clinical indices, psychometric scales and immunological indicators, the degree of the influence of stress on disease activity and on specific immune mechanisms was determined. The levels of cortisol, neuropeptides and key pro-inflammatory cytokines and the population of Th17 cells were analysed using correlation analysis. In addition, stable relationships between stress markers and the clinical activity of psoriasis were identified, which is an important indicator for the development of comprehensive psychoimmune therapeutic strategies.
Authors: Курбанов Шахбоз Ильхомович, Толибов Мансур Махмудович
Institution: Samarkand State Medical Institute
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W7115071107