Efficacy of Low-Dose Intravenous Immunoglobulin Combined With Immunosuppression Modification in the Treatment of BK Polyomavirus Nephropathy: A Case Series
Year: 2025
Type: article
Study design: Case Report
Abstract: New and powerful immunosuppression agents presently available for maintenance immunosuppression and for the treatment of acute and chronic rejection in renal transplantation have led to the emergence of opportunistic infections. One such infection is BK virus nephropathy, leading to graft dysfunction and graft loss. Apart from the reduction and manipulation of immunosuppressive medications, various treatment options such as intravenous immunoglobulin (IVIg), cidofovir, leflunomide, and fluoroquinolones have been tried to treat BK virus nephropathy. We report our experience with low-dose IVIg in six renal transplant recipients with BK polyomavirus nephropathy. We suggest that low-dose IVIg can be a promising treatment option to treat and prevent a decline in renal function and subsequent graft loss.
Source: Cureus
DOI: 10.7759/cureus.99218
Authors: Mahesh Eswarappa, Jaish George, Gurudev KC, Rajshekar R, Gireesh M S, Pooja Prakash Prabhu, Hamsa Reddy, Mohammad Yousuff, Rakesh Veluru
Institution: M.S. Ramaiah Medical College
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7115168422