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The role of cell adhesion molecule CD44 during prion disease

Year: 2025

Type: conference-paper

Abstract: Prion disease ( transmissible spongiform encephalopathies) are fatal, neurodegenerative disorders. Infection comes from misfolded prion protein (PrPSc) of normal host prion protein (PrPC) which accumulate in the brain. Characteristic changes include: reactive astrocyte activation with CD44 upregulation, microgliosis, neuronal vacuolation, and loss of neuronal connection through synaptic and dendritic spine depletion. Cluster of differentiation 44 (CD44) is a cell adhesion molecule and multi-functional protein, indicated to have roles in neurogenesis, synaptic and dendritic spine integrity, and astrocyte activation and morphology. Its role in prion disease, however, was unknown. We compared wild type and CD44 knockout (CD44-/-) mice to assess role of CD44 in prion neuropathogenesis and effects on astrocyte/microglia activation and morphology.

Source: Edinburgh Research Explorer (University of Edinburgh)

Authors: Bradford, Barry; id_orcid 0000-0002-4007-1685, Walmsley-Rowe, Lauryn, Reynolds, Joe, Verity, Nick, Mabbott, Neil; id_orcid 0000-0001-7395-1796

Language: English

Topic: Prion Diseases and Protein Misfolding

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7115290555

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