Associations of Moderate-to-Vigorous Physical Activity Timing with Type 2 Diabetes Incidence in UK Biobank and Glycemic measures in NHANES Running Title: MVPA timing and type 2 diabetes
Year: 2025
Type: article
Study design: Observational Study
Abstract: Objective: We assessed whether timing of accelerometer-derived moderate-to-vigorous physical activity (MVPA) was associated with incident Type 2 Diabetes (T2D) and glycemic measures, independent of total daily MVPA. Research design and methods: Hourly accelerometer-derived MVPA from UK Biobank (UKB) and NHANES were used as exposure. The associations between MVPA timing with incident T2D in UKB (N=84,528, prospective), and prevalent diabetes and glycemic measures in NHANES (N=6,998, cross-sectional) were assessed using regression models adjusted for confounders and total daily MVPA. Results: In UKB, compared to those undertaking early morning (05:00–9:59) MVPA, T2D risk was lower in people undertaking MVPA in afternoon-evening (15:00–24:00) (HR=0.73 [95%CI 0.61–0.87]), late morning-midday (10:00–14:59) (HR=0.83 [95%CI 0.70-0.98]). In NHANES, afternoon and early evening MVPA were weakly associated with more favorable glycemic measures and lower diabetes prevalence. Conclusions: MVPA during the afternoon-evening was associated with fewer incident T2D, prevalent diabetes and more favorable glycemic measures.
Authors: Feng, Qiuyu, Albalak, Gali, Ao, Linjun, Xiao, Qian, Wang, Heming, van der Velde, Jeroen H.P.M., Kiefte – de Jong, Jessica C, Rutter, Martin; id_orcid 0000-0001-6380-539X, Matthews, Charles E., Freeman, Joshua R., Willems van Dijk, Ko, van Heemst, Diana, van Heemst, Diana
Language: English
Topic: Physical Activity and Health
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7115389615
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