Process optimization for AAV-based gene therapy: insights on downstream purification
Year: 2024
Type: article
Abstract: In this article, Srivatsan Ramesh, Scientist, Downstream Process Development, BridgeBio discusses the critical challenges in downstream purification for AAV-based gene therapies, emerging technologies for viral vector characterization, in addition to methods for the robust translation of pre-clinical programs to clinical/commercial manufacturing. The importance of a holistic approach to process development—where both upstream and downstream processes are co-optimized—is highlighted.
Source: Cell and Gene Therapy Insights
Author: Srivatsan Ramesh
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W7115576732
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