Mastering AAV production: best practices for small to large-scale manufacturing success and reduced development times
Year: 2024
Type: article
Abstract: The article discusses the optimization and scalability of AAV production, highlighting the primary challenges in small-scale AAV production, such as long lead times, low titers, and high costs. The article further discusses the scalability of AAV production to commercial scales while maintaining performance and quality, and it presents best practices for achieving high AAV titers with a particular focus on the transfection step and optimizing plasmid ratios.
Source: Cell and Gene Therapy Insights
Author: Emily Jackson-Holmes
Institution: Thermo Fisher Scientific (United States)
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W7115578030
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