Demystifying AAV affinity capture: mapping AAV-affinity ligand footprints with cryo-electron microscopy
Year: 2024
Type: article
Abstract: Efficient and cost-effective purification is essential for achieving key objectives in AAV production including maximizing yield, maintaining product quality, and streamlining downstream processes. This poster highlights a study that leverages cryo-electron microscopy (cryo-EM) to map precise interactions between affinity ligands and AAV capsids. Combining robust resin performances—capable of 20+ clean-in-place cycles—with detailed molecular mapping optimizes capsid-resin compatibility, thereby reducing risks, saving time, and ensuring scalable, cost-effective downstream workflows.
Source: Cell and Gene Therapy Insights
Author: Nathaniel Clark
Institution: Repligen (United States)
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W7115580970
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