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A case of delayed-onset postoperative pyoderma gangrenosum complicated with chronic myelomonocytic leukemia treated with systemic corticosteroids and spesolimab

Year: 2025

Type: article

Abstract: Pyoderma gangrenosum (PG) constitutes an uncommon form of neutrophilic dermatosis frequently linked to systemic diseases, notably hematologic malignancies. Chronic myelomonocytic leukemia (CMML) provides a distinctive framework for the pathogenesis of PG, attributable to the mutual dysregulation of myeloid cell function. This case report documenting the delayed emergence of PG in conjunction with CMML postsurgery underscores the pivotal role of inhibiting the interleukin 36 (IL-36) pathway in managing PG associated with CMML.

Source: JAAD Case Reports

DOI: 10.1016/j.jdcr.2025.11.053

Authors: Gong Zhenni, Tao Siqi, He Li, Ma Xiaoya, Jia Xuesong, Ci Hai, Wang Xue

Institutions: Shihezi University, First Affiliated Hospital of Shihezi University Medical College

Language: English

Topic: Autoimmune and Inflammatory Disorders

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $750