Work

Characterization of the ketoreductase domain of pikromycin module 2

Year: 2025

Type: article

Abstract: )-3-hydroxy-2,4-dimethylheptanoic acid, indicating that the KR domain of PikAI-M2 is a B1-type. These findings offer insights into the unresolved classification of KR domains that do not strictly conform to the Caffrey motif.

Source: Chemical Science

DOI: 10.1039/d5sc07470c

Authors: Eiji Okamura, Kosuke Ohsawa, Hidetoshi Ban, Yoshiyuki Sugiyama, Junko Hashimoto, Kei Kudo, Masahito Yoshida, Kazuo Shin-ya, Haruo Ikeda, Shunji Takahashi, Takayuki Doi

Institutions: RIKEN Center for Sustainable Resource Science, Tohoku University, Juntendo University, Japan Biological Informatics Consortium, National Institute of Advanced Industrial Science and Technology, The University of Tokyo, University of Tsukuba, Kitasato University

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

Open Access status: diamond

Funders: Japan Agency for Medical Research and Development, Ministry of Education, Culture, Sports, Science and Technology, Japan Society for the Promotion of Science

Awards: G3299630088, Exploring lead compounds of actinomycetes based on genome mining using gene sequences of key enzymes for pharmacophore biosynthesis, G8534382553, 革新的中分子創薬技術の開発/中分子製造技術の開発

OpenAlex ID: W7115707371

FWCI: 0.483

Cites: 57

Cited by: 1

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