Year: 2025
Type: article
Abstract: With the acceleration of population aging, the prevalence of vascular calcification (VC) is on the rise, particularly among patients with hypertension, diabetes, chronic kidney disease, and age-related diseases. VC is characterized by the abnormal deposition of calcium phosphate in the vascular walls, and there are currently no effective pharmacological treatments available. This condition is a manifestation of vascular aging. The silent information regulator (SIRT) family, which includes SIRT1 to SIRT7, functions as deacetylases and plays a crucial role in cellular resistance, energy metabolism, apoptosis, and cellular aging, often referred to as longevity proteins. The SIRT family has shown potential in alleviating vascular aging by inhibiting inflammation, reducing endoplasmic reticulum stress, lowering mitochondrial oxidative stress, and promoting DNA damage repair, all of which contribute to the suppression of vascular calcification. Notably, SIRT1, SIRT2, SIRT3, SIRT6, and SIRT7 have demonstrated therapeutic potential in the treatment of vascular calcification.
Authors: Zhexue Ren, Beibei Song, Yinying Peng, Ce Bian, Qi Shen, Mengjun Zhou, Bo Li, Xiaodong Jin
Institutions: Weifang Medical University, Central Hospital of Zibo
Language: English
Subfield: Geriatrics and Gerontology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
Award: G7016980103
OpenAlex ID: W7115729055