COMPARISON OF PROFILES, ANTIOXIDANT, ENZYME INHIBITORY AND CYTOTOXIC CAPACITIES OF PHENOLIC EXTRACTS OF FIVE Teucrium SPECIES FROM TURKIYE
Year: 2025
Type: article
Abstract: The study aims to investigate the phenolic compounds, antioxidant-enzyme inhibitory activities, and cytotoxic effects of the flavonoid subgroups and phenolic acid extracts of the Teucrium chamaedrys ssp chamaedrys (TCC), T. chamaedrys ssp lydium (TCL), T. polium (TP), endemic T. alyssifolium (TA), T. kotschyanum (TK) from Türkiye.Among the phenolics determined, phenolic acids were found to be in the highest concentration, particularly caffeic, p-coumaric, and t-cinnamic acids.In term of antioxidant activity, the best IC50 values of 1,1-diphenyl-2-picrylhydrazyl (23.21±0.78µg/mL), hydroxyl (HO • ) (1.01±0.01µg/mL), nitric oxide scavenging (12.28±0.91 µg/mL) and metal chelating (20.10±0.66µg/mL) were determined in TP, TCL, TK, and TA, respectively.Additionally, TCL has a 5.05-times higher quenching capacity of HO • compared to butylated-hydroxytoluene.The best acetylcholinesterase and tyrosinase inhibitions were detected in TK and TCC, respectively.While the cytotoxic properties of these extracts against HepG2, OE-33, HeLa, ACC-201, and MCF-7 cancer cells were detected, more extensive effect was observed against HepG2 in TCC, TP, TA, and TCL.According to the results, the richness of Teucrium species in phenolic compounds, the importance of their antioxidantenzyme inhibitory properties and their cytotoxic effects make their potential as natural component sources in food and medical come to the fore.
Authors: RAZIYE OZTURK UREK, LEMAN TARHAN, YILDIZAY AYYILDIZ, MAHMURE NAKIBOGLU
Institution: Dokuz Eylül University
Language: English
Subfield: Biochemistry
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7115766945