Clinical recognition of frontotemporal dementia with right temporal predominance: a consensus statement from the International Working Group.
Year: 2024
Type: article
Abstract: Accurate diagnosis of frontotemporal dementia (FTD) with right anterior temporal lobe (RATL) predominance remains challenging due to lack of clinical characterization, and standardized terminology. The recent research of the International Working Group (IWG) identified common symptoms but also unveiled broad terminologies lacking precision and operationalization, with risk of misdiagnoses, inappropriate referrals and poor clinical management. Based on the published evidence (91267 articles screened) and expert opinion (105 FTD specialists across 52 centers) by using the nominal group technique, the IWG delineates three primary domains of impairment causing behavioral, memory and language problems: (i) multimodal knowledge of non-verbal information including people, living beings, landmarks, flavors/odors, sounds, bodily sensations, emotions and social cues; (ii) socioemotional behavior encompassing emotion expression, social response and motivation; and (iii) prioritization for focus on specific interests, hedonic valuation and personal preferences. This study establishes a consensus on clinical profile, phenotypic nomenclature, and future directions to enhance diagnostic precision and therapeutic interventions.
Source: Apollo (University of Cambridge)
Authors: Ulugut, Hulya, Younes, Kyan, Montembeault, Maxime, Bertoux, Maxime, Irish, Muireann, Kumfor, Fiona, Fumagalli, Giorgio G, Samanci, Bedia, Illán-Gala, Ignacio, Thompson, Jennifer C, Santillo, Alexander F, Englund, Elisabet, Landqvist Waldö, Maria, Riedl, Lina, Van den Stock, Jan, Vandenbulcke, Mathieu, Vandenberghe, Rik, Laforce, Robert, Ducharme, Simon, Pressman, Peter S, Caramelli, Paulo, Cruz de Souza, Leonardo, Takada, Leonel T, Gurvit, Hakan, Diehl-Schmid, Janine, Galimberti, Daniela, Pasquier, Florence, Weintraub, Sandra, Miller, Bruce L, Sturm, Virginia E, Whitwell, Jennifer L, Boeve, Bradley, Rohrer, Jonathan D, Piguet, Olivier, Gorno-Tempini, Maria Luisa, Josephs, Keith A, Snowden, Julie, Rowe, James B, Warren, Jason D, Rankin, Katherine P, Pijnenburg, Yolande AL, International rtvFTD working group
Institutions: University of California, San Francisco, Amsterdam Neuroscience, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Stanford University, Douglas Mental Health University Institute, McGill University Health Centre, McGill University, Inserm, Université de Lille, Lille Neurosciences & Cognition, LabEx DISTALZ, The University of Sydney, University of Milan, University of Trento, Istanbul University, Universitat Autònoma de Barcelona, Hospital de Sant Pau, Institut de Recerca Sant Pau, Biomedical Research Networking Center on Neurodegenerative Diseases
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: Alzheimer's Association, Wellcome Trust, Fondation Vaincre Alzheimer, Australian Government, National Brain Appeal, Alzheimer's Society, National Institute for Health and Care Research, KU Leuven, University College London Hospitals NHS Foundation Trust, National Institutes of Health, Medical Research Council, National Health and Medical Research Council, NIHR Cambridge Biomedical Research Centre, National Institute on Aging, National Institute on Deafness and Other Communication Disorders, National Institute of Neurological Disorders and Stroke
Awards: G1147870292, Enhancing the early and accurate diagnosis of frontotemporal dementia, G2493601830, G2537968379, G263490220, PIB PET Scanning in Speech and Language Based Dementias, G3126113876, Bridging the gap: biophysical models of human frontotemporal lobar degeneration, G4753630297, G54621210, Decision making and dementia: from mechanisms to clinical trials, From Nosology to Diagnosis; Right Temporal Variant Frontotemporal Dementia, Assessment of hyperphosphorylated tau PET binding in primary progressive aphasia
OpenAlex ID: W7115808869
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