Multi-Omics and Single-Cell Dissection of Exostosin Glycosyltransferases (EXT1/EXT2) Reveals Divergent Oncogenic Roles and Therapeutic Vulnerabilities in Gliomas
Year: 2025
Type: article
Abstract: contributes to extracellular matrix and cytoskeletal reprogramming. The exostosin axis represents a promising source of prognostic biomarkers and potential therapeutic targets in glioma.
Source: Journal of Cancer
DOI: 10.7150/jca.123965
Authors: Yi-Chun Chiang, Chih-Yang Wang, Neethu Palekkode, Shun-Fa Yang, Kai-Fu Chang, Ching-Chung Ko, Chih-Hsuan Chang, Hui-Ru Lin, Chi-Jen Wu, Yu-Cheng Ho, Chih-Chun Lin, Chien-Han Yuan, Sachin Kumar, Dahlak Daniel Solomon, Juan Lorell Ngadio, Fitria Sari Wulandari, Do Thi Minh Xuan, Chung-Bao Hsieh, Meng-Chi Yen, I-Jeng Yeh, Pi-Chan Ko, Chia-Lung Shih, Hoi-Bor Chan, Yung-Kuo Lee, Ngoc Uyen Nhi Nguyen
Institutions: Zuoying Armed Forces General Hospital, Kaohsiung Armed Forces General Hospital, Chung Shan Medical University, Taipei Medical University, Mother Teresa Women's University, Chung Shan Medical University Hospital, Tri-Service General Hospital, National Defense Medical Center, National Sun Yat-sen University, Chi Mei Medical Center, Chia Nan University of Pharmacy and Science, Kaohsiung Medical University, I-Shou University, Shoolini University, Indonesia International Institute for Life Sciences, Van Lang University, Kaohsiung Medical University Chung-Ho Memorial Hospital, Chia-Yi Christian Hospital, University of South Florida
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,337
OpenAlex ID: W7115905231