Work

Isolation of Four New Secondary Metabolites from the Cold Seep Chemosynthetic Ecosystem-Derived Fungus Arachnomyces bostrychodes

Year: 2025

Type: article

Abstract: Ultra performance liquid chromatography (UPLC)-high resolution (HR)MS/MS and feature-based molecular networking analysis were performed for the extract of a fungus, Arachnomyces bostrychodes, obtained from a cold seep chemosynthetic ecosystem, revealing the presence of new peptides. LC-MS-guided purification afforded three new cyclic tetrapeptides (3–5) containing two N-methyl-l-leucine residues. During the isolation procedure, a new benzophenone (1) and MDN-0093 (2) were isolated. Compounds 4 and 5 exhibited cytotoxicity against HeLa cells with IC50 values of 3.1 and 5.8 μM, respectively.

Source: Chemical and Pharmaceutical Bulletin

DOI: 10.1248/cpb.c25-00655

Authors: Tokuya Teshima, Yusaku Sadahiro, Yuki Hitora, Yuriko Nagano, Sachiko Tsukamoto

Institutions: Kumamoto University, Japan Agency for Marine-Earth Science and Technology

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

Open Access status: diamond

Funder: Japan Society for the Promotion of Science

Awards: α-synucleinの分解促進・凝集阻害作用を示す天然物の探索, Search for new p53 activating natural compounds as cancer therapeutic drugs and their functional analyses, G7478399207, 迅速な分子同定基盤に基づくp53凝集阻害物質の開発を目指した天然物創薬