Work

Disease and state dependent neural markers in adolescents with BD. Understanding the neural bases of mania, depression and remission in a data fusion approach

Year: 2025

Type: article

Abstract: • Limited knowledge exists about brain abnormalities across manic, depressed, and remitted subtypes in Pediatric bipolar disorder (PBD) • Resting-State Regional Homogeneity (ReHo) and Grey Matter Concentration (GMC) data were analyzed via data fusion unsupervised machine learning from 58 PBD patients and 21 healthy controls (HC) • Disease dependent and state dependent alterations were found, with a cortico-limbic network that differed between PBD and HC, cingulate and precuneus distinguished manic from depressed, fusiform and occipital regions were specific to depression compared to HC. The Default Mode Network differentiated manic from remitted states. • Findings provide new insights into the neural mechanisms underlying mood states in PBD. Pediatric bipolar disorder (PBD) is a severe and disabling condition marked by alternating episodes of mania and depression, intermitted with periods of remission. A critical challenge in the field is to elucidate the neural mechanisms underlying these distinct mood states, as manic and depressive presentations reflect profoundly different clinical phenotypes. Despite their relevance, the functional and structural brain alterations associated with manic, depressed, and remitted states in PBD remain poorly understood. In this study, data on Resting-State Regional Homogeneity (ReHo) and grey matter concentration (GMC) were considered from 58 PBD patients and 21 healthy controls (HC), matched for age, gender, education, and IQ. The analysis was conducted using Parallel ICA, a multivariate data-driven approach that identifies joint patterns of covariation across resting-state functional and gray matter features.. Among the nine RS-GM components identified, distinct disease- and state-dependent networks were detected. GM2, a cortico-limbic network, differentiated PBD from HC, suggesting a neural substrate of bipolar disorder independent of mood state. GM9, including the cingulate and the precuneus, distinguished manic from depressed states, while RS7, including the fusiform and occipital regions, was specific to depression compared to HC. RS1, including regions of the DMN, differentiated manic from remitted states. These findings provide new fresh understanding on the common and separate functional and structural abnormalities displayed during mania, depression and remission phases in bipolar patients.

Source: Psychiatry Research Neuroimaging

DOI: 10.1016/j.pscychresns.2025.112113

Authors: Xiaoping Yi, Xueying Wang, Mingzhao Ma, Jinfan Zhang, Feifei Wu, Haimiao Huang, Qian Xiao, Xiaoqun Liu, Alessandro Grecucci

Institutions: Chongqing University, Xiangya Hospital Central South University, Central South University, Second Xiangya Hospital of Central South University, University of Bari Aldo Moro

Language: English

Topic: Bipolar Disorder and Treatment

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,110