Work

MARCHF1-mediated SULF1 degradation blocks THBS2/TGF-β/SMAD2/3 signaling to reverse colon cancer metastasis and 5-FU resistance

Year: 2025

Type: article

Abstract: -endosulfatase 1 (SULF1) in CC cell proliferation, migration, apoptosis, and invasion. Through clinical samples and CC cell lines, we found that SULF1 promotes cell proliferation and survival, while inhibiting apoptosis, migration, and invasion. SULF1 interacts with thrombospondin-2 (THBS2) to regulate the transforming growth factor β 1 (TGF-β1)/SMAD family member 2/3 (SMAD2/3) pathway, promoting tumor progression. Membrane associated ring-CH-type finger 1 (MARCHF1) inhibits SULF1 function by accelerating its degradation, thereby suppressing CC cell growth and metastasis. Moreover, SULF1 silencing enhances sensitivity to 5-fluorouracil (5-FU) chemotherapy. In conclusion, targeting SULF1 and its regulatory network may provide new therapeutic strategies for CC.

Source: iScience

DOI: 10.1016/j.isci.2025.114476

Authors: Hui Li, Yong Xie

Institutions: Central South University, Second Xiangya Hospital of Central South University, Xiangya Hospital Central South University

Language: English

Topic: TGF-β signaling in diseases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,240