Work

A Rare Case Report of Uterine Carcinosarcoma in Patient with History of Breast Carcinoma

Year: 2025

Type: article

Abstract: Uterine carcinosarcoma (UCS), or malignant mixed Müllerian tumor, is a rare and aggressive uterine malignancy comprising malignant epithelial and mesenchymal components. We present the case of a 67-year-old postmenopausal woman with abdominal pain and anemia, and a history of breast carcinoma. Initial imaging suggested an endometrial polyp; biopsy was inconclusive. Persistent symptoms led to hysterectomy with bilateral salpingo-oophorectomy. Grossly, the uterus contained a bulky grey-white tumor (7x5x3 cm). Histopathology revealed serous adenocarcinoma (CK, p53 positive; ER negative) admixed with vimentin-positive homologous sarcoma, with >50% myometrial invasion; adnexa were uninvolved (FIGO stage IA). UCS has a poor prognosis and is occasionally linked to prior tamoxifen use, though hormonal therapy history was unavailable in this patient. This case highlights the need for suspicion of UCS in postmenopausal women with uterine masses and prior breast carcinoma, even without confirmed tamoxifen exposure. Early recognition and histopathologic confirmation are vital to guide management in this aggressive malignancy.

Source: Annals of Pathology and Laboratory Medicine

DOI: 10.21276/apalm.3672

Authors: Meenu Gill, Mahak, Biswasree Deb, Promil Jain, Geetika, Sunita Singh

Institutions: Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences, Pandit Bhagwat Dayal Sharma University of Health Sciences

Language: English

Topic: Endometrial and Cervical Cancer Treatments

Subfield: Obstetrics and Gynecology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7116095960

FWCI:

Cites:

Cited by:

Related to: