Indolent T-cell lymphoma of the gastrointestinal tract coexisting with gastric signet-ring cell carcinoma: A case report and review of literature
Year: 2025
Type: article
Study design: Case Report
Abstract: BACKGROUND: Edition World Health Organization Classification of Tumours of Haematolymphoid Tumours. However, the coexistence of iTCL-GI with epithelial malignancies is rare in clinical practice. This study reports a case of iTCL-GI with gastric signet-ring cell carcinoma (SRCC). We aim to increase diagnostic awareness among clinicians and pathologists regarding multiple primary tumors. CASE SUMMARY: A 65-year-old female presented with a 5-month history of lower abdominal pain, bloating, and vomiting. An abdominal computed tomography scan revealed irregular thickening of the gastric wall. Endoscopy revealed diffuse mucosal edema and rigid mucosa along the lesser curvature of the gastric body. There was a 1.5 cm mucosal protrusion on the greater curvature. Biopsy revealed that the lamina propria was expanded by a dense, nondestructive infiltrate of small lymphocytes in the greater curvature, which were characterized by a CD3+/CD8+/TIA-1+ immunophenotype with a low Ki-67 index. Clonal T-cell receptor rearrangement was detected, but the Epstein-Barr virus encoded RNA's was negative. Lesions on the lesser curvature of the gastric body were confirmed to be SRCCs. After three months of follow-up, the patient completed four cycles of chemotherapy targeting the SRCC. While her abdominal pain improved, she experienced a weight loss of 5 kg. CONCLUSION: Clinicians and pathologists must integrate assessment of these rare cases to prevent misdiagnosis and guide clinical practice.
Authors: Xue Chen, Jia-Qi Bo, Xiao-Xiang Gao, Su-Xia Zhang, Jie Li, Hui Wang, Mu-Ye Yang, Qian-Qian Guo, Bing Xiu, Yu Zeng
Institutions: Tongji University, Chinese People's Liberation Army
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W7116113935