Work

miR-19b-3p engineered adipose-derived stem cell exosomes attenuate acute liver failure via promoting tissue repair and microenvironment remodeling

Year: 2025

Type: article

Abstract: . Mechanistically, miR-19b-3p directly targeted p47phox (a NADPH oxidase subunit) and impede hepatic oxidative stress level. Then, the redox homeostasis changes inactivated NF-κB pathway by impeding iKBα ubiquitination and blocking nuclear translocation of NF-κB P65, and then triggered the damping of M1 macrophage polarization. Notably, miR-19-EXO also outperformed lentiviral miR-19b-3p or shp47phox delivery and conventional ROS scavengers in synergistic biological functions. Our finding paves the way of engineering ADSC-EXO to develop a proactive intervention strategy for ALF by increasing its specificity and functionality.

Source: Materials Today Bio

DOI: 10.1016/j.mtbio.2025.102697

Authors: Baitong Wu, Jiuxing Feng, Xi Wang, Jingyi Guo, Lanyue Sheng, Jian Wang, Jiaqi Xu, Jie Zhou, Guangming Wang, Yi Wen, Jiaxin Liu, Shu Zhao, Danjing Yang, Yinpeng Jin, Qingchun Fu, Jun Xu

Institutions: Tongji University, Shanghai East Hospital, Shanghai Medical College of Fudan University, Fudan University, Zhongshan Hospital, Guizhou Provincial People's Hospital, Shanghai Public Health Clinical Center

Language: English

Topic: Extracellular vesicles in disease

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,400

Funders: National Natural Science Foundation of China, China Postdoctoral Science Foundation, Shanghai Municipal Education Commission, Key Technologies Research and Development Program, National Key Research and Development Program of China

Awards: G1900747476, G2579668119, G3901649549, G4016724525, G5470575221, G5823350632

OpenAlex ID: W7116114809

FWCI:

Cites: 55

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