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Autoimmune HLA alleles and neoantigens predict myelodysplastic syndrome outcomes after allogeneic HSCT: A CIBMTR analysis

Year: 2025

Type: article

Abstract: = 0.021). Therefore, both autoimmune alleles and improved mutanome-derived neoantigen presentation correlated significantly and independently with relapse-free and OS, respectively, in a large multicenter group of MDS patients post-allo-HSCT. These factors warrant additional investigation for patient/donor selection.

Source: iScience

DOI: 10.1016/j.isci.2025.114326

Authors: Timothy Sears, Razelle Kurzrock, Tao Zhang, Jing Dong, Stephen R. Spellman, Aaron M. Goodman, Yung-Tsi Bolon, Zhongyuan Chen, Paul Auer, Wael Saber, Hannah Carter

Institutions: University of California San Diego, Medical College of Wisconsin, Medical College of Wisconsin Cancer Center, National Marrow Donor Program, Moores Cancer Center

Language: English

Topic: Hematopoietic Stem Cell Transplantation

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,240

Funders: Mark Foundation For Cancer Research, National Heart, Lung, and Blood Institute, National Cancer Institute, NHLBI Division of Intramural Research

Awards: Prognostic implications of mitochondrial inheritance in myelodysplastic syndromes after stem-cell transplantation, A Data Resource for Blood and Marrow Transplants and Adoptive Cellular Therapy Research

OpenAlex ID: W7116124464

FWCI:

Cites: 83

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