Work

Regulatory Mechanisms of NKG2DL Expression and Clinical Significance in Hepatocellular Carcinoma Cells

Year: 2025

Type: article

Abstract: Hepatocellular carcinoma (HCC) is a malignant tumor with high incidence and mortality rates worldwide, in which immune evasion mechanisms play a crucial role in its progression and treatment. Natural killer group 2D ligands (NKG2DL), as key molecules activating immune cells, significantly influence the immune evasion of liver cancer through their regulatory mechanisms. This review summarizes the regulatory mechanisms of NKG2DL expression, including genetic, signaling pathway, non-coding RNA, and stress response modulation, and discusses their expression patterns and clinical relevance in HCC. Studies have shown that the expression status of NKG2DL not only impacts patient prognosis and therapeutic response but also provides potential targets for HCC immunotherapy. Future research should focus on the molecular networks regulating their expression and their synergy with immunotherapy to provide a theoretical basis for developing more precise diagnostic and personalized treatment strategies for HCC.

Source: Gastroenterology and Hepatology Research

DOI: 10.14218/ghr.2025.00002

Authors: Qiqun Gu, Mei Wu, Chengyi Wan

Institutions: Shanghai University of Traditional Chinese Medicine, Shuguang Hospital

Language: English

Topic: Immune Cell Function and Interaction

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: National Natural Science Foundation of China