Figure 4 from MicroCT Enables Simultaneous Longitudinal Tracking of Murine Pancreatic Cancer Progression and Cachexia
Year: 2025
Type: other
Abstract: Longitudinal assessment of skeletal muscle wasting by microCT. A, Representative axial microCT image showing paraspinal muscle cross-section at the L5 vertebra (red outline)—the region used for area measurements. B, 3D reconstruction of microCT scan showing L5 paraspinal muscles (red) in the coronal and sagittal planes. C, Longitudinal tracking of paraspinal muscle area, expressed as a percentage of baseline for mice injected with different PDAC lines or PBS control. D, Postmortem analysis of gastrocnemius, tibialis anterior, and quadriceps muscle weights normalized to initial body weight across experimental groups (N = 4 per group). Statistical analysis used one-way ANOVA with Dunnett multiple comparisons test. ns, not significant; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001. Error bars represent the mean ± SD.
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W7116684974