Recombinant ADAMTS‑1 promotes muscle regeneration accompanied by downregulation of Notch signaling
Year: 2025
Type: article
Abstract: . These levels were particularly elevated in the high‑dose rADAMTS‑1 group and remained sustained until day 14. Grip strength recovered to normal levels by day 7 in the high‑dose rADAMTS‑1 group, suggesting improved functional recovery compared with the untreated controls. In vitro, rADAMTS‑1 treatment induced a dose‑dependent increase in muscle fiber length and upregulation of regeneration‑related factors in primary skeletal muscle cells. Furthermore, C2C12 cells treated with rADAMTS‑1 exhibited enhanced expression of myocyte developmental genes during differentiation. The findings highlighted the therapeutic potential of rADAMTS‑1 for sarcopenia, potentially addressing limitations associated with conventional MuSC‑based treatments.
Institution: Chungnam National University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W7116727608
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