Figure 2 from MicroCT Enables Simultaneous Longitudinal Tracking of Murine Pancreatic Cancer Progression and Cachexia
Year: 2025
Type: other
Abstract: Longitudinal monitoring of PDAC tumor kinetics using microCT imaging and volumetric comparisons with 2D US. A, Representative axial microCT image showing the primary tumor (red outline). B, 3D reconstruction showing the primary tumor (red) and skeleton of the mouse rendered in grayscale. C, Correlation of primary tumor volume measured by microCT with tumor weight at endpoint (N = 27, Pearson’s r = 0.9734; P < 0.0001; R2 = 0.9475). D, Schematic and representative US images showing how primary tumor volume was estimated by 2D US. Axial and sagittal slices at the largest tumor dimensions were obtained, and area (A) and height (H) measurements were used to derive cylindrical volumes for each plane. Tumor volumes were calculated by averaging the volumes of the axial and sagittal cylinders and applying a spherical volume correction factor (2/3). E, Correlation between US- and microCT-derived primary tumor volumes (R2 = 0.6349, P = 0.0011). F, Correlation between US- and microCT-derived primary tumor volumes for subset of tumors smaller than 700 mm3 (as determined by microCT; R2 = 0.00, P = 0.9839).
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W7116747240